Prognostic Factors of Wilms’ Tumor Complicated with Nephroblastomatosis

IntroductIon Nephrogenic rests (NRs) are abnormally persistent clusters of embryonal cells, representing microscopic dysplasias of the developing kidney. NRs are found in approximately 1% of infant kidneys at autopsy. Nephroblastomatosis signifies the presence of multiple or diffuse NRs. Both NRs and nephroblastomatosis were known as precursor lesions of Wilms’ tumor.[1] Nephroblastomatosis can be classified into four categories: Perilobar (PLNR only); intralobar (ILNR only); combined (PLNR and ILNR); and universal. The diagnosis and treatment of Wilms’ tumor have been improved constantly and achieved common sense. However, little information is available regarding Wilms’ tumor associated with nephroblastomatosis for lower prevalence. This study aimed to investigate the prognostic factors of Wilms’ tumor associated with nephroblastomatosis.